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Cancer Stem Cells

Cancer Stem Cells

Cancer stem cells (CSCs) are increasingly being recognized as the key determinative cells of malignancies. CSCs are described as relatively quiescent cells capable of self-renewal and the generation of more differentiated daughter cells that constitute the bulk of the tumor mass. While there is still debate as to the existence of a single subset of CSCs versus a collection of CSC variants in some tumors, a growing body of literature links CSCs to all steps of tumorigenesis, from initiation to metastasis. Even more ominously, however, evidence suggests that these cells are responsible for therapeutic resistance and relapse, with their persistence often meaning a poor clinical prognosis. For these reasons, CSC biology has become a vigorously studied area of cancer research.

Cancer Stem Cells Markers

Breast Colon Glioma Liver Lung Melanoma Ovarian Pancreatic Prostate
ALDH1 ABCB5 A2B5 ALDH1 ABCG2 ABCB5 ALDH1 ABCG2 A2B1
CD24 ALDH1 CD15 CD13 ALDH1 ALDH1 CD24 ALDH1 ALDH1
CD44 CD24 CD90 CD24 CD90 CD20 CD44 CD24 CD24
CD90 CD26  CD133 CD44 CD117 CD34 CD117 CD44 CD44
CD133 CD29  α6-integrin CD90 CD133 CD117 CD133 CD133  CD133
α6-integrin CD44  Nestin CD133   CD133   c-Met  CD166
EpCAM CD133   EpCAM   CD166   CXCR4  α2β1-integrin
p63 CD166   ICAM1   CD271   Nestin  α6-integrin
  EpCAM   Sall4   Nestin   EpCAM  
  LGR5              

 

Selected Cancer Stem Cells Markers

     

ALDH1A1 antibody (GTX123973)

c-Met antibody [C3], C-term (GTX100637)

  

Integrin beta 1 / CD29 antibody (GTX128839)

 
 
 

CD44 antibody [GT462] (GTX628895)

   

CD54 / ICAM1 antibody [N1C2](GTX100450)

CD90/Thy1 antibody (GTX130072)

 
 

EpCAM antibody [N3C3] (GTX113091)

Nestin antibody [GT623] (GTX630201)

 
   
 
Pathways
Wnt Pathway

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Flyer - Cancer Stem Cells

Flyer - Cancer Stem Cells

Download the latest version of GeneTex's cancer stem cells flyer
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Flyer - Cancer Stem Cells

Flyer - Cancer Stem Cells

Download the latest version of GeneTex's cancer stem cells flyer