GeneTex
United States (US)
Cancer Immune Checkpoints

Cancer Immune Checkpoints

Increasing knowledge of how cancer cells escape immune destruction has significantly driven the evolution of cancer immunotherapy. In particular, studies describing how different immune checkpoints, including the PD-1 and CTLA-4 pathways, function to attenuate T cell antitumor activity have revealed novel opportunities for therapeutic intervention. Researchers have made promising strides in inhibiting these checkpoints to unleash the T cells’ tumor-killing potential. Given that both radiotherapy and chemotherapy can also mobilize antitumor T cells, there is great excitement that checkpoint inhibition and other immunomodulatory approaches can be combined with conventional modalities to maximize clinical outcomes for a number of malignancies.

Highlighted Products

    

VPD-1 antibody (GTX20256)

 

CTLA4 antibody  (GTX75812)

CD134 antibody [OX86] (GTX74991)

 
 

Arginase1 antibody (GTX109242)

 

iNOS antibody (GTX130246)

FOXP3 antibody  (GTX80283)

 
 

TNF alpha antibody (GTX110520)

 

IFN gamma antibody (GTX31185)

 

CD80 antibody  (GTX84701)

 
 

CD86 antibody  (GTX41787)

 

CD137 antibody [17B5] (GTX42758)

 

CD137L antibody (GTX117355)

 
 
 

CD276 Antibody (GTX42152)

CD28 antibody (GTX33959)

 

ICOS antibody (GTX129570)

 
 
 

CD525 antibody  (GTX42201)

 

TIM-3 antibody  (GTX54054)

LAG3 antibody (GTX42244)

 
 

CD40 antibody (GTX101447)

CD4 antibody (GTX44531)

   
Pathways
Wnt Pathway

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Flyer - Cancer Immune Checkpoints

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpointss flyer
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Flyer - Cancer Immune Checkpoints

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpointss flyer