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ATM antibody [2C1] (supernatant)

Anti-ATM antibody [2C1] (supernatant) used in Western Blot (WB). GTX77613
Anti-ATM antibody [2C1] (supernatant) used in IHC (Paraffin sections) (IHC-P). GTX77613
Anti-ATM antibody [2C1] (supernatant) used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX77613

Cat. No. GTX77613

Reference 227

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2C1

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IP, IHC

Reactivity

 Human, Mouse, Rat, Monkey
Package
1000 μl ($399)
See all ATM products

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1:100.
For IP: Use at an assay dependent dilution.
For IHC: Use at 1:50. Analysis was performed of the cerebral cortex of E14.5 wild-type (+/+) and scid mice - (MC Vemuri, 2001) For immunofluorescence please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006.
For ICC/IF: Use at 1:500.
Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

351 kDa. ( Note )

Positive Control

Raji and lymphoblastoid nuclear lysate

PROPERTIES

Form

Liquid

Buffer

TCS

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.

Purification

Unpurified
From hybridoma culture supernatant

Conjugation

Unconjugated

RRID

AB_377546

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATM serine/threonine kinase , AT1 , ATA , ATC , ATD , ATDC , ATE , TEL1 , TELO1

Cellular Localization

Nucleus , Cytoplasmic vesicle

Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

Database

Research Area

DATA IMAGES

Anti-ATM antibody [2C1] (supernatant) used in Western Blot (WB). GTX77613

GTX77613 WB Image

Sample (30 ug of whole cell lysate)

A: 293T

B: A431

C: HeLa

D: HepG2

5% SDS PAGE

GTX77613 diluted at 1:100

Anti-ATM antibody [2C1] (supernatant) used in IHC (Paraffin sections) (IHC-P). GTX77613

GTX77613 IHC-P Image

Immunohistochemical analysis of paraffin-embedded Hepatoma, using ATM(GTX77613) antibody at 1:50 dilution.

Anti-ATM antibody [2C1] (supernatant) used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX77613

GTX77613 ICC/IF Image

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ATM(GTX77613) antibody at 1:100 dilution.

REFERENCE

Clone Reference

Sible E et al. J Immunol 2023; 210 (4):369-376 Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination.
Kim YH et al. Cells 2022; 11 (18) Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation.
Fangfang Wang et al. Acta Pharm Sin B 2022; 12 (3):1339-1350 Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR.
Yang SC et al. Int J Mol Sci 2022; 23 (3) Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines.
Zhang L et al. Nat Commun 2022; 13 (1):360 53BP1 regulates heterochromatin through liquid phase separation.
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REVIEW

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Application Reference
Li J et al. J Biol Chem 2005; 280 (12):12041-50 Regulation of CHK2 by DNA-dependent protein kinase.
Application : WB
Reactivity : Human
Kozlov S et al. J Biol Chem 2003; 278 (11):9309-17 ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.
Application : WB
Perkins EJ et al. Genes Dev 2002; 16 (2):159-64 Sensing of intermediates in V(D)J recombination by ATM.
Reactivity : Mouse
Vemuri MC et al. Cell Death Differ 2001; 8 (3):245-55 Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Reactivity : Mouse
Scherthan H et al. Mol Cell Biol 2000; 20 (20):7773-83 Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Reactivity : Mouse
Clone Reference
Sible E et al. J Immunol 2023; 210 (4):369-376 Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination.
Li J et al. Nucleic Acids Res 2022; 50 (18):10503-10525 APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus.
Zhang Y et al. iScience 2022; 25 (10):105115 RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11.
Kim YH et al. Cells 2022; 11 (18) Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation.
Fangfang Wang et al. Acta Pharm Sin B 2022; 12 (3):1339-1350 Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR.
Yang SC et al. Int J Mol Sci 2022; 23 (3) Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines.
Zhang L et al. Nat Commun 2022; 13 (1):360 53BP1 regulates heterochromatin through liquid phase separation.
Bulut-Karslioglu A et al. Nat Commun 2021; 12 (1):4859 Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells.
Teng YN et al. Cells 2021; 10 (6) Etoposide Triggers Cellular Senescence by Inducing Multiple Centrosomes and Primary Cilia in Adrenocortical Tumor Cells.
Chen TY et al. Cell Death Differ 2021; (Epub) Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response.
Saito Y et al. J Cell Sci 2020; 133 (12) RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner.
Pan YR et al. Biomolecules 2020; 10 (11)
Geng X et al. Biochem Pharmacol 2020; 182:114226 Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction.
Wang CY et al. Drug Des Devel Ther 2020; 14:2987-3000 Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis.
Jo DS et al. Autophagy 2020;:2023/1/15 Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy.
Jingwen Li et al. RSC Adv 2019; 9 (67):39082-39089 New spirobisnaphthalenes from an endolichenic fungus strain CGMCC 3.15192 and their anticancer effects through the P53-P21 pathway.
Tang M et al. Sci Adv 2019; 5 (3):eaav1118 SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
Lu X et al. Nucleic Acids Res 2019; 47 (21):10977-10993 GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival.
Bakkenist CJ et al. DNA Repair (Amst) 2019; 80:2023/1/7 Quantitative analysis of ATM phosphorylation in lymphocytes.
Shen TS et al. Molecules 2019; 24 (13) Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation.
Shen M et al. J Exp Clin Cancer Res 2019; 38 (1):149
Gupta R et al. J Immunol 2019; 202 (10):2924-2944 Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins.
Liu Q et al. bioRxiv 2018; (Epub) Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining.
Tu HJ et al. Clin Epigenetics 2018; 10 (1):162 The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Chen CC et al. Cancers (Basel) 2018; 10 (9) Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair.
Li Z et al. Cell Res 2018; (Epub) Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.
Karlin J et al. Mol Cancer Ther 2018; (Epub) Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice.
Gu X et al. Toxicol Lett 2018; (Epub) Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Chen XF et al. EMBO Rep 2018; (Epub) SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Li FL et al. Nat Commun 2018; 9 (1):508 acetylation accumulates pfkfb3 in cytoplasm to promote glycolysis and protects cells from *-induced apoptosis.
Molenaar RJ et al. Clin Cancer Res 2018; (Epub) IDH1/2 mutations sensitize acute myeloid leukemia to PARP inhibition and this is reversed by IDH1/2-mutant inhibitors.
Z Chen et al. Hum. Mol. Genet. 2017; (Epub) LRRK2 Interacts with ATM and Regulates Mdm2-p53 Cell Proliferation Axis in Response to Genotoxic Stress.
Vanessa Mordasini et al. Oncotarget 2017; 8 (4):6461-6474 Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells.
Clarke TL et al. Mol Cell 2017; 65 (5):900-916.e7 PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.
Lien WC et al. J Cell Biochem 2017; (Epub) 7-hydroxy-staurosporine, UCN-01, induces DNA damage response and autophagy in human osteosarcoma U2-OS cells.
Karayazi Atici O et al. Endocrinology 2017; (Epub) ATM is required for the prolactin-induced HSP90-mediated increase in cellular viability and clonogenic growth after DNA damage.
Dyer LM et al. Breast Cancer Res Treat 2017; (Epub) ATM is required for SOD2 expression and homeostasis within the mammary gland.
Enari M et al. Methods Mol Biol 2017; 1599:145-156 Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS).
Mai Y et al. Blood 2016; 128 (24):2797-2807 an oxidative stress-based mechanism of * cytotoxicity suggests new therapeutic strategies in abc-dlbcl.
Yang Z et al. Sci Transl Med 2016; 8 (331):331ra38 Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
Salzman DW et al. Nat Commun 2016; 7:10954 miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.
Kuo CY et al. Cell Cycle 2016; 15 (6):787-98 RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
Wang Y et al. Genes Dev 2016; 30 (3):293-306 A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.
Federico MB et al. PLoS Genet 2016; 12 (1):e1005792 Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.
You J et al. Cancer Lett 2016; (Epub) SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
Mehta M et al. Oncotarget 2016; HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy.
Inoue S et al. Cancer Cell 2016; 30 (2):337-48 Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
He D et al. Sci Rep 2016; 6:24504 The dynamic behavior of Ect2 in response to DNA damage.
Shisuo Du et al. International Journal of Radiation Oncology*Biology*Physics 2015; 1 (91):91-99 Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non–Small-Cell Lung Cancer Cells In-Vitro and In-Vivo?
Zhang J et al. Nat Cell Biol 2015; 17 (10):1259-1269 ATM functions at the peroxisome to induce pexophagy in response to ROS.
Gibbs-Seymour I et al. Aging Cell 2015; 14 (2):162-9 Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
Burla R et al. PLoS Genet 2015; 11 (6):e1005167 AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Bakkenist CJ et al. Oncoscience 2015; 2 (5):542-54 A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.
Zellweger R et al. J Cell Biol 2015; 208 (5):563-79 Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
Kijas AW et al. Nucleic Acids Res 2015; 43 (17):8352-67 ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Chou WC et al. Carcinogenesis 2015; 36 (8):832-40 Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
Saquilabon Cruz GM et al. Nucleic Acids Res. 2015; (Epub) Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.
Nakajima NI et al. PLoS One 2015; 10 (3):e0122582 Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
Ruan X et al. J Mol Cell Biol 2015; 7 (2):105-18 P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.
Kumari A et al. DNA Repair (Amst) 2015; 28:73-82 BLM protein mitigates formaldehyde-induced genomic instability.
Ray Chaudhuri A et al. Mol Cell Biol 2015; 35 (5):856-65 Poly(ADP-Ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.
Lim YC et al. Mol Oncol 2014; (Epub) Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells
Guo J et al. PLoS One 2014; 9 (2):e88140 Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.
Kuo CY et al. J Biol Chem 2014; 289 (30):20757-72 An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Kruppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.
Werner E et al. PLoS One 2014; 9 (10):e108234 Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.
So EY et al. Cell Death Dis 2014; 5:e1418 Translational initiation regulated by ATM in dendritic cells development.
Ouchi M et al. Cancer Biol Ther 2014; 15 (12):1700-4 Distinct DNA damage determines differential phosphorylation of Chk2.
Ayrapetov MK et al. Proc Natl Acad Sci U S A 2014; 111 (25):9169-74 DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.
Sajish M et al. Nature 2014; (Epub) A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Du F et al. Biochem Biophys Res Commun 2014; 452 (4):1034-9 Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair.
Hennig J et al. Cell Death Dis 2014; 5:e1199 APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.
Kotov IN et al. Mol Oncol 2014; Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.
Li LH et al. PLoS One 2014; 9 (8):e104203 hinokitiol induces dna damage and autophagy followed by cell cycle arrest and senescence in *-resistant lung adenocarcinoma cells.
Lee JH et al. PLoS One 2014; 9 (6):e97969 Direct Activation of ATM by Resveratrol under Oxidizing Conditions.
Wang CY et al. Oncogene 2014; DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
Sharma NK et al. DNA Repair (Amst) 2014; 13:22-31 Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.
Biddlestone-Thorpe L et al. Clin Cancer Res 2013; 19 (12):3189-200 ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.
Lim HC et al. PLoS One 2013; 8 (9):e74334 Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.
Cottarel J et al. J Cell Biol 2013; 200 (2):173-86 A noncatalytic function of the ligation complex during nonhomologous end joining.
Murad NA et al. Mitochondrion 2013; 13 (3):235-45 Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Bowen C et al. Cell Rep 2013; 4 (3):516-29 Functional activation of ATM by the prostate cancer suppressor NKX3.1.
Tripathi DN et al. Proc Natl Acad Sci U S A 2013; 110 (32):E2950-7 Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
Zhang X et al. PLoS One 2013; 8 (5):e62527 Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential.
Lee JH et al. J Biol Chem 2013; 288 (18):12840-51 Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
Stewart R et al. Hum Mol Genet 2013; 22 (12):2495-509 A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
Wu CW et al. PLoS One 2013; 8 (2):e57036 MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer.
Choi SY et al. Nucleic Acids Res 2013; 41 (4):2180-90 Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress.
Shi Y et al. BMC Cancer 2012; 12:571 starvation-induced activation of atm/chk2/p53 signaling sensitizes cancer cells to *.
Nayler S et al. Stem Cells Transl Med 2012; 1 (7):523-35 Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype.
Sakasai R et al. Genes Cells 2012; 17 (12):962-70 CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Dellago H et al. Aging (Albany NY) 2012; 4 (4):290-304 ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Ai L et al. J Biol Chem 2012; 287 (22):18330-41 Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Zhang J et al. Proc Natl Acad Sci U S A 2012; 109 (16):E926-33 Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Kang MA et al. J Biol Chem 2012; 287 (20):16246-55 Deregulation of DNA damage response pathway by intercellular contact.
Hao Z et al. J Exp Med 2012; 209 (1):173-86 The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Shi Y et al. PLoS One 2012; 7 (9):e45354 differential effects of * on * responses in normal human mesothelial cells versus cancer cells: implication for therapy.
Baritaud M et al. Cell Death Dis 2012; 3:e390 AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
Hardee ME et al. Cancer Res 2012; 72 (16):4119-29 Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
Mahajan K et al. J Biol Chem 2012; 287 (26):22112-22 Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
Hsu CC et al. J Biol Chem 2012; 287 (27):22533-48 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
Sugimoto N et al. J Biol Chem 2011; 286 (45):39200-10 Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
Brown JA et al. Mol Cell Biol 2011; 31 (22):4417-29 A novel role for hSMG-1 in stress granule formation.
Luo K et al. J Biol Chem 2011; 286 (32):28192-9 Oligomerization of MDC1 protein is important for proper DNA damage response.
Bouquet F et al. J Cell Sci 2011; 124 (Pt 11):1943-51 A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Chen Y et al. Cell Cycle 2011; 10 (4):655-63 Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Matsumoto Y et al. DNA Repair (Amst) 2011; 10 (3):314-21 Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Xu Y et al. Int J Biochem Mol Biol 2011; 2 (4):295-302 The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase.
Assaily W et al. Mol Cell 2011; 44 (3):491-501 ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Hada M et al. Mutat Res 2011; 716 (43102):76-83 AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Gatei M et al. J Biol Chem 2011; 286 (36):31542-56 ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Shouse GP et al. Oncogene 2011; 30 (35):3755-65 ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
Cherubini G et al. Nucleic Acids Res 2011; 39 (13):5459-73 The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
Urquhart AJ et al. Genome Integr 2011; 2 (1):1 ATM mediated phosphorylation of CHD4 contributes to genome maintenance.
Ruiz Z et al. Virology 2011; 410 (2):375-84 Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM).
Kozlov SV et al. J Biol Chem 2011; 286 (11):9107-19 Autophosphorylation and ATM activation: additional sites add to the complexity.
Xu Y et al. J Cell Biol 2010; 191 (1):31-43 The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
Huang QM et al. Cancer Res 2010; 70 (21):8407-16 Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.
Storch K et al. Cancer Res 2010; 70 (10):3925-34 Three-dimensional cell growth confers radioresistance by chromatin density modification.
Bowen C et al. Cancer Res 2010; 70 (8):3089-97 NKX3.1 activates cellular response to DNA damage.
Kongruttanachok N et al. Mol Cancer 2010; 9:70 Replication independent DNA double-strand break retention may prevent genomic instability.
Sakasai R et al. DNA Repair (Amst) 2010; 9 (1):76-82 Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.
Papp LV et al. Antioxid Redox Signal 2010; 12 (7):797-808 SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.
Guo Z et al. Cell Cycle 2010; 9 (24):1061336 ATM activation in the presence of oxidative stress.
Powell MD et al. Proteomics Clin Appl 2010; 4 (3):337-51 Discovery of putative oocyte quality markers by comparative ExacTag proteomics.
Shanware NP et al. PLoS One 2010; 5 (8):e12173 Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.
Lee JH et al. Proc Natl Acad Sci U S A 2010; 107 (33):14639-44 Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Fang Z et al. Genome Integr 2010; 1 (1):9 Low levels of ATM in breast cancer patients with clinical radiosensitivity.
Ousset M et al. Cell Cycle 2010; 9 (14):2814-22 Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.
Sakasai R et al. J Biol Chem 2010; 285 (20):15201-8 Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Wilhelm MT et al. Genes Dev 2010; 24 (6):549-60 Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Kodama M et al. Mol Cell Biol 2010; 30 (7):1620-33 Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Hu H et al. Proc Natl Acad Sci U S A 2010; 107 (4):1506-11 ATM is down-regulated by N-Myc-regulated microRNA-421.
Yoshida K et al. J Cell Sci 2010; 123 (Pt 2):225-35 CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
Bolderson E et al. Nucleic Acids Res 2010; 38 (6):1821-31 Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.
Britton S et al. Cancer Res 2009; 69 (20):2271962 ARTEMIS nuclease facilitates apoptotic chromatin cleavage.
Sun Y et al. Nat Cell Biol 2009; 11 (11):1376-82 Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Sugimoto N et al. J Cell Sci 2009; 122 (Pt 8):1184-91 Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Cui B et al. Mol Pharmacol 2009; 75 (6):1356-63 Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Heffernan TP et al. J Invest Dermatol 2009; 129 (7):1805-15 ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
Hein J et al. J Virol 2009; 83 (1):117-27 Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
Martin LJ et al. Cereb Cortex 2009; 19 (6):1273-93 Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.
So S et al. J Cell Biol 2009; 187 (7):977-90 Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
Nahas SA et al. Clin Chem 2009; 55 (3):463-72 Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Chou WC et al. EMBO J 2008; 27 (23):3140-50 Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Meulle A et al. PLoS One 2008; 3 (10):e3345 Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Ariumi Y et al. J Virol 2008; 82 (19):9639-46 The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Stohr BA et al. Cancer Res 2008; 68 (13):5309-17 ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Sugimoto N et al. Mol Biol Cell 2008; 19 (3):1007-21 Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Lai CK et al. Virology 2008; 370 (2):295-309 Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.
Luo H et al. J Biol Chem 2008; 283 (28):19176-83 Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.
Yalcin S et al. J Biol Chem 2008; 283 (37):25692-705 Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Rimkus SA et al. Genes Dev 2008; 22 (9):1205-20 Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.
Wei G et al. Cancer Res 2008; 68 (7):2214-22 Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
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