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Filaggrin antibody

Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695
Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695
Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695
Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695

Cat. No. GTX37695

Reference 10

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all Filaggrin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-500 (based on 0.5 mg/ml)
Not tested in other applications.

Calculated MW

435 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human Filaggrin.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_11178768

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

filaggrin , ATOD2

Background

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

Database

Research Area

DATA IMAGES

Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695

GTX37695 IHC-P Image

Filaggrin antibody detects Filaggrin protein at cell membrane by immunohistochemical analysis.
Sample: Paraffin-embedded mouse skin.
Filaggrin stained by Filaggrin antibody (GTX37695) diluted at 1:200.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695

GTX37695 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX37695 Filaggrin antibody.
Dilution : 2.5μg/ml

Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695

GTX37695 IHC-P Image

IHC-P analysis of rat stomach tissue using GTX37695 Filaggrin antibody.
Dilution : 2.5μg/ml

Anti-Filaggrin antibody used in IHC (Paraffin sections) (IHC-P). GTX37695

GTX37695 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX37695 Filaggrin antibody.
Dilution : 2.5μg/ml

REFERENCE

Application Reference

Kim SY et al. Evid Based Complement Alternat Med 2022; 2022 : 4520433 Effects of Oral Administration of <i>Lactiplantibacillus Plantarum</i> APsulloc 331261 (GTB1<sup>TM</sup>) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models.
Kim EY et al. J Ethnopharmacol 2021; 281 : 114453 Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models.
Application : IHC-P
Reactivity : Mouse
Kitazawa K et al. Commun Biol 2021; 4 (1) : 114 Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis.
Application : IHC-P
Reactivity : Mouse
Kim SH et al. Nutrients 2020; 12 (1) Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice Through Modulating Immune Balance and Skin Barrier Function.
Reactivity : Mouse
Lee CW et al. Biomolecules 2020; 10 (4) Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes.
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REVIEW

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Application Reference
Kim SY et al. Evid Based Complement Alternat Med 2022; 2022:4520433 Effects of Oral Administration of <i>Lactiplantibacillus Plantarum</i> APsulloc 331261 (GTB1<sup>TM</sup>) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models.
Kim EY et al. J Ethnopharmacol 2021; 281:114453 Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models.
Application : IHC-P
Reactivity : Mouse
Kitazawa K et al. Commun Biol 2021; 4 (1):114 Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis.
Application : IHC-P
Reactivity : Mouse
Kim SH et al. Nutrients 2020; 12 (1) Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice Through Modulating Immune Balance and Skin Barrier Function.
Reactivity : Mouse
Lee CW et al. Biomolecules 2020; 10 (4) Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes.
Song C et al. Cell Biol Toxicol 2019; (Epub) Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium.
Reactivity : Human, Mouse
Lee CW et al. Int J Mol Sci 2019; 20 (17) Water-Soluble Fullerenol C60(OH)36 toward Effective Anti-Air Pollution Induced by Urban Particulate Matter in HaCaT Cell.
Reactivity : Human
Kim K.P. et al. Nutrition Research 2018; (Epub) Borage oil restores acidic skin pH by up-regulating the activity or expression of filaggrin and enzymes involved in epidermal lactate, free fatty acid, and acidic free amino acid metabolism in essential fatty acid-deficient Guinea pigs.
He K et al. Sci Rep 2017; 7 (1):13685 Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation.
Application : IHC-P
Reactivity : Human
Xiong Z et al. J Pathol 2017; (Epub) PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-esophageal epithelium.
Application : IHC-P
Reactivity : Mouse
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399