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Human Papillomavirus type 16/18 E6 antibody

Cat. No. GTX20070

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Isotype

 IgG1

Application

 WB, IHC-P, IP

Reactivity

 Human papillomavirus
Package
100 μg ($399)
See all Human Papillomavirus type 16/18 E6 products

APPLICATION

Application Note

Recommended Starting Dilutions: For IP: Use at an assay dependant dilution. For IHC-P: Use at an assay dependant dilution. For WB: Use at a dilution of 1:100-1:2000. Optimal dilutions/concentrations should be determined by the end user.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human papillomavirus

Immunogen

Gel-purified HPV-18 E6-beta galactosidase fusion protein

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_379630

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Human papillomavirus Protein E6 , Human papillomavirus E6 , HPV virus Protein E6 , HPV virus E6

Background

The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.

Research Area

REFERENCE

Application Reference

Gunder LC et al. Viruses 2023; 15 (4) Topical Protease Inhibitor Decreases Anal Carcinogenesis in a Transgenic Mouse Model of HPV Anal Disease.
Shi M et al. J Pathol 2012; 228 (2) : 148-57 Glucocorticoid regulation of a novel HPV-E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells.
Application : WB

Clone Reference

Abdulkarim B et al. Oncogene 2002; 21 (15):2334-46 Antiviral agent * restores p53 function and enhances the radiosensitivity in HPV-associated cancers.
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REVIEW

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Package List Price ($)
$ 399
Custom Conjugations